Sleep disorders and risk of dementia in patients with new-onset type 2 diabetes: A nationwide population-based cohort study

J Diabetes. 2021 Feb;13(2):101-110. doi: 10.1111/1753-0407.13092. Epub 2020 Aug 20.


Background: This study examined the relationship between sleep disorders and the risk of dementia in patients with newly diagnosed type 2 diabetes.

Methods: This study used the Korean Health Screening Cohort data and included 39 135 subjects aged ≥40 years with new-onset type 2 diabetes between 2004 and 2007, with follow-up throughout 2013. Sleep disorders were measured by F51(sleep disorders not due to a substance or known physiological condition) or G47(sleep disorders) under International Classification of Diseases, Tenth Revision (ICD-10) codes as a primary diagnosis, and the adjusted hazard ratio (AHR) and 95% CI of all-cause dementia, Alzheimer disease, vascular dementia, and other dementia were estimated using multivariable Cox proportional hazards regression models.

Results: In the patients with type 2 diabetes with an age range between 42 and 84 years (M = 57.8, SD = 9.5), this study identified 2059 events of dementia during an average follow-up time of 5.7 years. In patients with type 2 diabetes, subjects with sleep disorders were associated with an increased risk of all-cause dementia (AHR, 1.46; 95% CI, 1.19-1.80), Alzheimer disease (AHR, 1.39; 95% CI, 1.02-1.88), and other dementia (AHR, 1.69; 95% CI, 1.23-2.31) compared to those without sleep disorders. Men (AHR, 1.93; 95% CI, 1.42-2.62) and older adults (AHR, 1.70; 95% CI, 1.35-2.15) with sleep disorders were associated with an increased risk of dementia than their counterparts without sleep disorders among patients with type 2 diabetes.

Conclusions: These findings suggest that sleep disorders are significantly associated with an increased risk of dementia in patients with new-onset type 2 diabetes.

背景: 本研究探讨了新发2型糖尿病患者睡眠障碍与痴呆风险之间的关系。 方法: 本研究使用韩国健康筛查队列数据,纳入了2004年至2007年之间39135名年龄≥40岁的新发2型糖尿病患者,并在2013年进行了随访。根据国际疾病分类(ICD-10)代码作为主要诊断依据F51(不是物质或已知生理状况引起的睡眠障碍)或G47(睡眠障碍)来测量睡眠障碍,并使用多变量Cox比例风险回归模型估算了全因痴呆、阿尔茨海默病、血管性痴呆和其他痴呆的调整危险比(adjusted hazard ratio ,AHR)和95%置信区间。 结果: 在年龄42至84岁之间的2型糖尿病患者(M = 57.8,SD = 9.5)中,该研究确定了平均随访时间为5.7年的2059例痴呆事件。在2型糖尿病患者中,与没有睡眠障碍的人相比睡眠障碍患者与全因痴呆(AHR,1.46; 95%CI,1.19-1.80)、阿尔茨海默病(AHR,1.39; 95%CI,1.02-1.88),及其他痴呆症(AHR,1.69; 95%CI,1.23-2.31)的患病风险增加相关。患有睡眠障碍的男性2型糖尿病患者(AHR,1.93; 95%CI,1.42-2.62)和老年人(AHR,1.70; 95%CI,1.35-2.15)与没有睡眠障碍的患者相比,患有痴呆症的风险增加。 结论: 这些发现表明睡眠障碍与新发2型糖尿病患者痴呆风险增加显著相关。.

Keywords: 2型糖尿病; dementia; sleep disorders; type 2 diabetes; 痴呆; 睡眠障碍.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dementia / epidemiology*
  • Dementia / etiology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Risk
  • Sleep Wake Disorders / complications
  • Sleep Wake Disorders / epidemiology*