Update on Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) - review

Rom J Intern Med. 2020 Dec 17;58(4):199-208. doi: 10.2478/rjim-2020-0017. Print 2020 Dec 1.


Human herpesvirus 8 (HHV8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for diagnosis and treatment. Therefore, ongoing studies are trying to answer the main issues related to the management of KSHV infection and its associated diseases. This review updates the current knowledge of the KSHV infection, discussing aspects related to epidemiology, virological features, clinical manifestations, diagnosis and treatment.

Keywords: KSHV; Kaposi sarcoma; Kaposi sarcoma-associated herpesvirus; multicentric Castleman disease; primary effusion lymphoma.

Publication types

  • Review

MeSH terms

  • Herpesviridae Infections* / diagnosis
  • Herpesviridae Infections* / epidemiology
  • Herpesviridae Infections* / immunology
  • Herpesviridae Infections* / therapy
  • Herpesvirus 8, Human / pathogenicity
  • Humans
  • Sarcoma, Kaposi / classification
  • Sarcoma, Kaposi / diagnosis
  • Sarcoma, Kaposi / therapy
  • Sarcoma, Kaposi / virology*