The Effect of Comorbidities on Wound Healing

Surg Clin North Am. 2020 Aug;100(4):695-705. doi: 10.1016/j.suc.2020.05.002. Epub 2020 Jun 17.


Wound healing is affected by several factors. Preexisting diagnoses may significantly alter, delay, or inhibit normal wound healing. This is most commonly seen with chronic disorders, such as diabetes and renal failure, but also occurs secondary to aging and substance abuse. Less commonly, genetic or inflammatory disorders are the cause of delayed wound healing. In some cases, it is not the illness, but the treatment that can inhibit wound healing. This is seen in patients getting chemotherapy, radiation, steroids, methotrexate, and a host of other medications. Understanding these processes may help treat or avoid wound healing problems.

Keywords: Comorbidities; Delayed wound healing; Wound healing.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Antineoplastic Agents / adverse effects
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / physiopathology
  • Chronic Disease
  • Genetic Diseases, Inborn / complications
  • Genetic Diseases, Inborn / physiopathology
  • Humans
  • Infections / complications
  • Infections / physiopathology
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / physiopathology*
  • Nutrition Disorders / complications
  • Nutrition Disorders / physiopathology
  • Radiation Injuries / complications
  • Radiation Injuries / physiopathology
  • Skin / radiation effects
  • Skin Diseases / complications
  • Skin Diseases / physiopathology
  • Smoking / adverse effects
  • Smoking / physiopathology
  • Wound Healing / physiology*
  • Wounds and Injuries / complications
  • Wounds and Injuries / physiopathology*


  • Antineoplastic Agents