Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity

Diabetes Res Clin Pract. 2020 Aug;166:108331. doi: 10.1016/j.diabres.2020.108331. Epub 2020 Jul 17.

Abstract

Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece.

Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020.

Results: The median age of the patients was 65.5 (IQR 56-73), majority were male (80%) and obesity was present in 34.4% of patients most prevalent to younger than 55 years. Hypertension was the prevailing comorbidity (50%), followed by cardiovascular diseases (21.1%) and type-2 diabetes (18.9%). At admission, common symptoms duration had a median of 8 (IQR 5-11) days. A 13.3% of the patients were discharged, 53.4% were still in the ICUs and 28.9% deceased who were hospitalised for fewer days than the survivors [6 (IQR 3-9) vs. 9 (IQR 7-14.5) respectively]. Aging was not a risk factor but diabetes deteriorates the outcomes. Obesity poses a suggestive burden as it was more notable in deceased versus survivors.

Conclusions: Type 2 diabetes and obesity may have contributed to disease severity and mortality in COVID-19 critically ill patients in Greece.

Keywords: Covid-19; Critically ill; Greece; Intensive Care Unit; Obesity; Type-2 diabetes.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Betacoronavirus / isolation & purification*
  • Comorbidity
  • Coronavirus Infections / complications
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / mortality*
  • Coronavirus Infections / virology
  • Critical Illness / mortality*
  • Diabetes Mellitus / mortality*
  • Diabetes Mellitus / physiopathology
  • Diabetes Mellitus / virology
  • Female
  • Greece / epidemiology
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Obesity / mortality*
  • Obesity / physiopathology
  • Obesity / virology
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / mortality*
  • Pneumonia, Viral / virology
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Survival Rate

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2