Association of XPG rs17655G>C and XPF rs1799801T>C Polymorphisms with Susceptibility to Cutaneous Malignant Melanoma: Evidence from a Case-Control Study, Systematic Review and Meta-Analysis

Klin Onkol. 2020 Spring;33(3):184-194. doi: 10.14735/amko2020184.


Background: Previous studies have evaluated associations of XPG rs17655G>C and XPF rs1799801T>C polymorphisms with a risk of cutaneous malignant melanoma (CMM). However, their results thus remained inconsistent or even contradictory. Thus, the aim of this meta-analysis was to evaluate association of XPG rs17655G>C and XPF rs1799801T>C polymorphism with a risk of CMM.

Methods: A comprehensive literature search was performed on PubMed, Web of Science, Scopus, SciELO and CNKI databases up to October 15, 2019 to identify relevant studies. Moreover, a case-control study was conducted to evaluate association of XPF rs1799801T>C with CMM risk in the Iranian population. The odds ratio (OR) and 95% confidence interval (CI) values were used to estimate the strength of the associations.

Results: Total of 12 studies including 9 studies with 5,362 cases and 7,195 controls on XPG rs17655G>C and 3 studies with 803 CMM cases and 737 controls on XPF rs1799801T>C were selected. Pooled data revealed that XPF rs1799801T>C polymorphism was significantly associated with an increased risk of CMM under the heterozygote model (CT vs. TT: OR = 1.313; 95% CI 1.062-1.624; P = 0.012). However, XPG rs17655G>C polymorphism was not significantly associated with the risk of CMM in the overall population and by ethnicity. The subgroup analysis showed a significant association between XPG rs17655G>C polymorphism and CMM in polymerase chain reaction-based restriction fragments length polymorphism (PCR-RFLP) group of studies.

Conclusion: This meta-analysis result revealed that XPF rs1799801T>C polymorphism may be a risk factor for developing of CMM. However, our pooled data inconsistence with the previous meta-analyses revealed that XPG rs17655G>C polymorphism was not associated with the risk of CMM.

Keywords: XPF; XPG; association; cutaneous malignant melanoma; meta-analysis; polymorphism.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Case-Control Studies
  • DNA-Binding Proteins / genetics*
  • Endonucleases / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Melanoma / genetics*
  • Melanoma, Cutaneous Malignant
  • Nuclear Proteins / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Skin Neoplasms / genetics*
  • Transcription Factors / genetics*


  • DNA excision repair protein ERCC-5
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors
  • xeroderma pigmentosum group F protein
  • Endonucleases