De Ritis ratio and biochemical parameters in COVID-19 patients

Arch Physiol Biochem. 2022 Dec;128(6):1676-1680. doi: 10.1080/13813455.2020.1788604. Epub 2020 Jul 20.

Abstract

Background: The study aimed to examine some biochemical test parameters and De Ritis ratio in COVID-19 patients, considering age and gender.

Method: The study was performed on patients with real-time polymerase chain reaction and computed tomography lung diagnosis. The relationship between lactate dehydrogenase, creatine kinase (CK), creatine kinase-MB, alanine aminotransferase, aspartate aminotransferase and De Ritis ratio were analysed in the first blood samples of the patients. The difference between gender was also compared with the independent sample t-test. Alpha value was accepted <0.05.

Results: The De Ritis was significantly higher in females (p = .040). The De Ritis ratio was associated with CK in both gender. There was no significant difference in the biochemical parameters according to gender.

Conclusion: The De Ritis ratio appears to be a parameter that can be used in COVID-19 patients. However, more detailed and comprehensive studies including the symptoms of patients are needed.

Keywords: ALT; AST; CK; CK-MB; COVID-19; De Ritis ratio; LDH.

MeSH terms

  • Alanine
  • Alanine Transaminase
  • Aspartate Aminotransferases
  • COVID-19*
  • Creatine Kinase
  • Female
  • Humans
  • L-Lactate Dehydrogenase
  • Retrospective Studies

Substances

  • Aspartate Aminotransferases
  • Alanine Transaminase
  • L-Lactate Dehydrogenase
  • Creatine Kinase
  • Alanine