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. 2020 Jul 6;4(5):731-736.
doi: 10.1002/rth2.12372. eCollection 2020 Jul.

A proposal for staging COVID-19 coagulopathy

Jecko Thachil  1 , Mary Cushman  2 , Alok Srivastava  3
Affiliations
Free PMC article

A proposal for staging COVID-19 coagulopathy

Jecko Thachil et al. Res Pract Thromb Haemost. .
Free PMC article

Abstract

Coronavirus disease 2019 (COVID-19) is associated with significant hypercoagulability. However, despite prophylactic anticoagulation, critically ill patients with this condition develop thromboses. This forum discusses the lungs as the epicenter for the hemostatic issues, puts forward a proposal for staging COVID-19 coagulopathy based on available diagnostic markers, and suggest considering current and future treatment options based on these different stages.

Keywords: COVID‐19; anticoagulation; thrombosis.

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Figures

FIGURE 1
FIGURE 1
The 3 stages of COVID‐19–associated hemostatic abnormalities (CAHA). In stage 1, regions of microthrombi could be identified throughout the peripheral parenchyma. In stage 2, this extends to most of the lung. In stage 3, further coagulation activation becomes systemic thrombi. aPTT, activated partial thromboplastin time; ICU, intensive care unit; PT, prothrombin time
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