Platelet function in stroke/transient ischemic attack patients treated with tocotrienol

FASEB J. 2020 Sep;34(9):11838-11843. doi: 10.1096/fj.201902216RR. Epub 2020 Jul 20.

Abstract

The purpose of this study was to characterize the effects of tocotrienol form of vitamin E (TCT) on platelet function in patients with stroke or transient ischemic attack (TIA). A double blind, randomized, single center phase II clinical trial was conducted comparing placebo (PBO) and 400 and 800 mg TCT daily for a year in 150 patients with a sentinel ischemic stroke or TIA event in the prior 6 months. Platelet function was measured at baseline and then, at 3 month intervals for a year, using light transmission aggregometry. The incidence of aspirin resistance in aspirin-treated patients or platelet inhibition in patients on clopidogrel alone was compared between the three treatment groups. Results showed that in patients taking aspirin and clopidogrel, the incidence of aspirin resistance was significantly decreased from 40% in PBO-treated patients to 9% in the 400 mg TCT group and 25% in the TCT 800 mg group (P = .03). In conclusion, patients on aspirin and clopidogrel had a higher incidence of aspirin resistance than all patients treated with aspirin alone and TCT decreased the frequency of aspirin resistance in this group.

Keywords: aspirin resistance; clinical trial; nutrition; vitamin E.

Publication types

  • Clinical Trial, Phase II
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aspirin / therapeutic use*
  • Clopidogrel / therapeutic use*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Ischemic Attack, Transient / drug therapy*
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Stroke / drug therapy*
  • Tocotrienols / administration & dosage
  • Tocotrienols / therapeutic use*
  • Vitamins / therapeutic use

Substances

  • Platelet Aggregation Inhibitors
  • Tocotrienols
  • Vitamins
  • Clopidogrel
  • Aspirin