Drug Discovery for Thirsty Crops

Jorge Lozano-Juste; Irene García-Maquilón; Rafael Ruiz-Partida; Pedro L Rodriguez

doi:10.1016/j.tplants.2020.07.001

Drug Discovery for Thirsty Crops

Trends Plant Sci. 2020 Sep;25(9):844-846. doi: 10.1016/j.tplants.2020.07.001. Epub 2020 Jul 18.

Authors

Jorge Lozano-Juste¹, Irene García-Maquilón², Rafael Ruiz-Partida², Pedro L Rodriguez²

Affiliations

¹ Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas - Universidad Politécnica de Valencia, 46022, Valencia, Spain. Electronic address: lojujo@ibmcp.upv.es.
² Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas - Universidad Politécnica de Valencia, 46022, Valencia, Spain.

PMID: 32690361
DOI: 10.1016/j.tplants.2020.07.001

Abstract

Following virtual screening and structure-based ligand optimization, researchers have developed opabactin (OP), an abscisic acid (ABA)-receptor agonist with tenfold greater in vivo activity than ABA. This new ligand surpasses previous agonists for its potency and bioactivity on staple crops. OP leads a new class of agrochemicals designed to protect crops from drought.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abscisic Acid
Arabidopsis Proteins*
Crops, Agricultural
Droughts
Drug Discovery

Substances

Arabidopsis Proteins
Abscisic Acid