Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

doi:10.1136/gutjnl-2020-321949

Comment

. 2021 Mar;70(3):620-621.

doi: 10.1136/gutjnl-2020-321949. Epub 2020 Jul 20.

Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

Chun-Han Lo^{1

2}, Sohee Kwon^{2

3}, Liang Wang^{1

4}, Georgios Polychronidis^{1

5

6}, Markus D Knudsen^{1

7

8}, Rong Zhong^{1

9

10}, Yin Cao^{11

12}, Kana Wu¹³, Shuji Ogino^{1

10

14}, Edward L Giovannucci^{1

13

15}, Andrew T Chan^{2

3

14

15

16}, Mingyang Song^{17

2

3

13}

Affiliations

¹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
² Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
³ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁴ Center of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
⁵ Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
⁶ Study Centre of the German Surgical Society, University of Heidelberg, Heidelberg, Germany.
⁷ Section of Bowel Cancer Screening, Cancer Registry of Norway, Oslo, Norway.
⁸ Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.
⁹ Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
¹⁰ Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
¹² Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
¹³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
¹⁴ Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
¹⁵ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
¹⁶ Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
¹⁷ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA mis911@mail.harvard.edu.

PMID: 32690603
PMCID: PMC7855151
DOI: 10.1136/gutjnl-2020-321949

Comment

Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

Chun-Han Lo et al. Gut. 2021 Mar.

. 2021 Mar;70(3):620-621.

doi: 10.1136/gutjnl-2020-321949. Epub 2020 Jul 20.

Authors

Affiliations

¹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
² Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
³ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁴ Center of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
⁵ Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
⁶ Study Centre of the German Surgical Society, University of Heidelberg, Heidelberg, Germany.
⁷ Section of Bowel Cancer Screening, Cancer Registry of Norway, Oslo, Norway.
⁸ Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.
⁹ Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
¹⁰ Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
¹² Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
¹³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
¹⁴ Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
¹⁵ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
¹⁶ Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
¹⁷ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA mis911@mail.harvard.edu.

PMID: 32690603
PMCID: PMC7855151
DOI: 10.1136/gutjnl-2020-321949

No abstract available

Keywords: gastric cancer; oesophageal cancer.

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Conflict of interest statement

Competing interests: ATC previously served as a consultant for Bayer Healthcare and Pfizer for work unrelated to the topic of this manuscript. All remaining authors have declared no conflicts of interest.

Figures

**Figure 1.. Multivariable-adjusted hazard ratio of esophageal adenocarcinoma and gastric adenocarcinoma across history of periodontal disease and tooth loss.**
Cox proportional hazards models were stratified by age (continuous, month), cohort (NHS, HPFS), and study period (in 2-year intervals) and adjusted for the same covariates as the full model in Table 1. P for interaction between periodontal disease and tooth loss was calculated by including a cross-product interaction term between periodontal disease and tooth loss in the model and estimating the significance using the likelihood ratio test.

See this image and copyright information in PMC

Comment on

Mucosal microbiome dysbiosis in gastric carcinogenesis.
Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J. Coker OO, et al. Gut. 2018 Jun;67(6):1024-1032. doi: 10.1136/gutjnl-2017-314281. Epub 2017 Aug 1. Gut. 2018. PMID: 28765474 Free PMC article.

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References

1. Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 2018;67:1024–32. - PMC - PubMed
1. Peters BA, Wu J, Pei Z, et al. Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res 2017;77:6777–87. - PMC - PubMed
1. Gao S, Li S, Ma Z, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agents Cancer 2016;11:3. - PMC - PubMed
1. Yuan X, Liu Y, Kong J, et al. Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract. Cancer Letters 2017;404:1–7. - PubMed
1. Michaud DS, Fu Z, Shi J, et al. Periodontal disease, tooth loss, and cancer risk. Epidemiologic Reviews 2017;39:49–58. - PMC - PubMed

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[1] Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 2018;67:1024–32. - PMC - PubMed

[2] Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 2018;67:1024–32. - PMC - PubMed

[3] Peters BA, Wu J, Pei Z, et al. Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res 2017;77:6777–87. - PMC - PubMed

[4] Peters BA, Wu J, Pei Z, et al. Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res 2017;77:6777–87. - PMC - PubMed

[5] Gao S, Li S, Ma Z, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agents Cancer 2016;11:3. - PMC - PubMed

[6] Gao S, Li S, Ma Z, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agents Cancer 2016;11:3. - PMC - PubMed

[7] Yuan X, Liu Y, Kong J, et al. Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract. Cancer Letters 2017;404:1–7. - PubMed

[8] Yuan X, Liu Y, Kong J, et al. Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract. Cancer Letters 2017;404:1–7. - PubMed

[9] Michaud DS, Fu Z, Shi J, et al. Periodontal disease, tooth loss, and cancer risk. Epidemiologic Reviews 2017;39:49–58. - PMC - PubMed

[10] Michaud DS, Fu Z, Shi J, et al. Periodontal disease, tooth loss, and cancer risk. Epidemiologic Reviews 2017;39:49–58. - PMC - PubMed

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Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

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Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

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