Scavenger receptors

Curr Biol. 2020 Jul 20;30(14):R790-R795. doi: 10.1016/j.cub.2020.05.051.

Abstract

Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets. The functional mechanisms that lead to their clearance of harmful substances involve phagocytosis, endocytosis, adhesion, and signaling.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alarmins
  • Animals
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / therapy
  • Endocytosis
  • Humans
  • Immunity, Innate
  • Inflammation
  • Ligands
  • Macrophages / metabolism
  • Molecular Targeted Therapy
  • Neurodegenerative Diseases / etiology
  • Pathogen-Associated Molecular Pattern Molecules
  • Phagocytosis
  • Receptors, Scavenger / chemistry
  • Receptors, Scavenger / classification
  • Receptors, Scavenger / metabolism*
  • Receptors, Scavenger / physiology*
  • Signal Transduction
  • Toll-Like Receptors

Substances

  • Alarmins
  • Ligands
  • Pathogen-Associated Molecular Pattern Molecules
  • Receptors, Scavenger
  • Toll-Like Receptors