Carotid and cerebrovascular dual-energy computed tomography angiography: Optimization of window settings for virtual monoenergetic imaging reconstruction

Eur J Radiol. 2020 Sep:130:109166. doi: 10.1016/j.ejrad.2020.109166. Epub 2020 Jul 9.

Abstract

Purpose: Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA.

Methods: Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard linearly-blended (M_0.6), 70-keV traditional VMI (M70), and 40-keV noise-optimized VMI (M40+) reconstructions were analyzed. For M70 and M40+ datasets, the subjectively best window setting (width and level, B-W/L) was independently determined by two observers and subsequently related with aortic arch attenuation to calculate optimized values (O-W/L) using linear regression. Subjective evaluation of image quality (IQ) between W/L settings were assessed by two additional readers. Repeated measures analysis of variance were performed to compare W/L settings and IQ indices between M_0.6, M70, and M40 + .

Results: B-W/L and O-W/L for M70 were 580/210 and 560/200, and for M40+ were 1630/570 and 1560/550, respectively, higher than standard DE-CTA W/L settings (450/100). Highest subjective scores were observed for M40+ regarding overall IQ (all p < 0.001).

Conclusion: Application of O-W/L settings is mandatory to optimize subjective IQ of VMI reconstructions of DE-CTA.

Keywords: Carotid disease; Computed tomography; Computed tomography angiography; Dual-energy; Image postprocessing.

MeSH terms

  • Aged
  • Carotid Arteries / diagnostic imaging
  • Carotid Artery Diseases / diagnostic imaging*
  • Cerebrovascular Disorders / diagnostic imaging
  • Computed Tomography Angiography / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radiographic Image Interpretation, Computer-Assisted / methods*
  • Radiography, Dual-Energy Scanned Projection / methods*
  • Reproducibility of Results
  • Retrospective Studies
  • Signal-To-Noise Ratio