Diagnosis and treatment of microspherophakia

J Cataract Refract Surg. 2020 Dec;46(12):1674-1679. doi: 10.1097/j.jcrs.0000000000000334.


As a rare congenital disease, microspherophakia (MSP) is characterized by small and spherically shaped crystalline lenses. The common complications of MSP include secondary glaucoma and crystalline lens dislocation or subluxation. Patients with MSP often show high lenticular myopia. The special morphological characteristics and complex complications bring challenges to the treatment of patients with MSP. Although there are some studies on MSP, most are case reports. In this article, the morphological characteristics, complications, genetic diagnosis, and treatment of MSP were systematically reviewed, providing valuable insight into the clinical diagnosis and treatment of this disease.

Publication types

  • Systematic Review

MeSH terms

  • Corneal Diseases
  • Ectopia Lentis* / diagnosis
  • Ectopia Lentis* / genetics
  • Ectopia Lentis* / surgery
  • Glaucoma* / diagnosis
  • Glaucoma* / surgery
  • Humans
  • Iris / abnormalities
  • Lens Implantation, Intraocular
  • Lens Subluxation* / diagnosis
  • Lens Subluxation* / etiology
  • Lens Subluxation* / surgery
  • Lens, Crystalline*
  • Visual Acuity

Supplementary concepts

  • Microspherophakia