Magnetically Actuated Manipulation and Its Applications for Cartilage Defects: Characteristics and Advanced Therapeutic Strategies

Chi Zhang; You-Zhi Cai; Xiang-Jin Lin; Yue Wang

doi:10.3389/fcell.2020.00526

Magnetically Actuated Manipulation and Its Applications for Cartilage Defects: Characteristics and Advanced Therapeutic Strategies

Front Cell Dev Biol. 2020 Jun 30:8:526. doi: 10.3389/fcell.2020.00526. eCollection 2020.

Authors

Chi Zhang^{1

2}, You-Zhi Cai^{1

2}, Xiang-Jin Lin¹, Yue Wang^{1

3}

Affiliations

¹ Center for Sport Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
³ Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Abstract

For the fact that articular cartilage is a highly organized and avascular tissue, cartilage defects are limited to spontaneously heal, which would subsequently progress to osteoarthritis. Many methods have been developed to enhance the ability for cartilage regeneration, among which magnetically actuated manipulation has attracted interests due to its biocompatibility and non-invasive manipulation. Magnetically actuated manipulation that can be achieved by introducing magnetic nanoparticles and magnetic field. This review summarizes the cutting-edge research on the chondrogenic enhancements via magnetically actuated manipulation, including cell labeling, cell targeting, cell assembly, magnetic seeding and tissue engineering strategies.

Keywords: cartilage regeneration; magnetic cell sheets; magnetic nanoparticles; magnetic scaffolds; magnetic seeding; magnetically actuated manipulation.

Publication types

Review