Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial

Amino Acids. 2020 Aug;52(8):1115-1124. doi: 10.1007/s00726-020-02876-7. Epub 2020 Jul 21.


Taurine (Tau), an endogenous non-protein and sulfuric-amino acid, is involved in various biological pathways including anti-inflammatory, anti-oxidation, insulin resistance inhibition, and lipid profile improvement. According to some experimental and clinical studies, insulin resistance and excess body weight are associated with reduced serum level of Tau. Therefore, this study was aimed to evaluate Tau supplementation and a diet-induced weight-loss intervention on body composition and some biochemical indices of obese women. Participants were divided randomly into the intervention (standard weight-loss group + cap Tau 3 g/day for 8 weeks, n = 20) and control (standard weight-loss group + cap placebo for 8 weeks, n = 18) groups. To achieve weight loss, all participants received an individualized diet that included a 30% reduction in their total energy intake. Chi-square test was applied to compare categorical variables between two groups at baseline. Paired t test and independent-sample t test were also used to analyze the parametric continuous data within and between the two groups, respectively. Analysis of covariance was run for controlling the confounding variables. At the post-intervention, the mean changes of total cholesterol (p = 0.03), low-density lipoprotein cholesterol (p = 0.03), leptin (p = 0. 006), total adiponectin (p = 0.04), and high sensitivity C-reactive protein (p = 0.03) decreased significantly in Tau group compared with the control group. No significant results were found in the mean changes of high-density lipoprotein cholesterol, anthropometric measurements, glycemic indices, and liver enzymes between the two groups (p > 0.05). The findings showed that Tau supplementation along with a weight-loss diet may be more effective in improving the lipid profile and metabolic risk factors compared with a weight-loss diet alone.

Keywords: Adipokines; Glycaemic indices; Lipid profile; Obesity; Taurine; Weight loss diet.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood
  • Adiponectin / metabolism
  • Adult
  • Biomarkers / blood
  • Biomarkers / metabolism
  • Body Composition / drug effects*
  • C-Reactive Protein / analysis
  • C-Reactive Protein / metabolism
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / metabolism
  • Diet, Reducing*
  • Dietary Supplements*
  • Energy Intake
  • Female
  • Glycemic Index / drug effects
  • Humans
  • Leptin / blood
  • Middle Aged
  • Obesity / diet therapy*
  • Taurine / administration & dosage
  • Taurine / pharmacology*
  • Weight Loss / drug effects


  • Adiponectin
  • Biomarkers
  • Cholesterol, LDL
  • Leptin
  • Taurine
  • C-Reactive Protein