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Comparative Study
. 2020 Jul 1;3(7):e2016382.
doi: 10.1001/jamanetworkopen.2020.16382.

Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection

Denise J McCulloch  1 , Ashley E Kim  1 , Naomi C Wilcox  1 , Jennifer K Logue  1 , Alex L Greninger  2 , Janet A Englund  3 , Helen Y Chu  1
Affiliations
Comparative Study

Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection

Denise J McCulloch et al. JAMA Netw Open. .

Abstract

This diagnostic study compares unsupervised home self-collected midnasal swabs vs clinician-collected nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Chu reported consulting with GlaxoSmithKline and Merck and receiving research funding from Sanofi Pasteur, Cepheid, and Ellume outside of the submitted work. Dr Greninger reported receiving personal fees from Abbott Molecular outside of the submitted work. Dr Englund reported consulting with Sanofi Pasteur and Meissa Vaccines outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Cycle Thresholds (Ct) for Home Self-collected Midnasal Swabs and Clinician-Collected Nasopharyngeal (NP) Swabs
Home self-collected midnasal swab (n = 28) Ct values were positively associated with the paired clinician-collected nasopharyngeal swab (n = 30) Ct value (correlation coefficient, 0.81; P = 5.1 × 10−6). The Ct values were calculated from a severe acute respiratory syndrome coronavirus 2 reverse transcriptase–polymerase chain reaction assay that targets 2 distinct regions of the virus, using Centers for Disease Control and Prevention primers and probes for the virus nucleocapsid (N) gene, N1 and N2.
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References

    1. Seaman CP, Tran LTT, Cowling BJ, Sullivan SG. Self-collected compared with professional-collected swabbing in the diagnosis of influenza in symptomatic individuals: a meta-analysis and assessment of validity. J Clin Virol. 2019;118:28-35. doi:10.1016/j.jcv.2019.07.010 - DOI - PubMed
    1. He Z, Zhuang H, Zhao C, Dong Q, Peng G, Dwyer DE. Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV). Virol J. 2007;4:32. doi:10.1186/1743-422X-4-32 - DOI - PMC - PubMed
    1. Zou L, Ruan F, Huang M, et al. . SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177-1179. doi:10.1056/NEJMc2001737 - DOI - PMC - PubMed
    1. Wikramaratna P, Paton RS, Ghafari M, Lourenco J Estimating false-negative detection rate of SARS-CoV-2 by RT-PCR. medRxiv. Preprint posted online April 14, 2020. doi:10.1101/2020.04.05.20053355 - DOI - PMC - PubMed
    1. Chu HY, Englund JA, Starita LM, et al. ; Seattle Flu Study Investigators . Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform. N Engl J Med. 2020. doi:10.1056/NEJMc2008646 - DOI - PMC - PubMed

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