Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

doi:10.1001/jamanetworkopen.2020.16485

. 2020 Jul 1;3(7):e2016485.

doi: 10.1001/jamanetworkopen.2020.16485.

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

Pierre Francois Laterre¹, Bruno François², Christine Collienne¹, Philippe Hantson¹, Robin Jeannet³, Kenneth E Remy^{4

5

6}, Richard S Hotchkiss^{5

6

7}

Affiliations

¹ Department of Critical Care Medicine, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
² Intensive Care Unit Department and Inserm Centre Investigation Clinique 1435 and Unité Mixte de Recherche 1092, University Hospital of Limoges, Limoges, France.
³ Department of Intensive Care Medicine and Anaesthesiology, University Hospital of Limoges, Limoges, France.
⁴ Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁵ Department of Anesthesiology and Critical Care Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁶ Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁷ Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri.

PMID: 32697322
PMCID: PMC7376391
DOI: 10.1001/jamanetworkopen.2020.16485

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

Pierre Francois Laterre et al. JAMA Netw Open. 2020.

. 2020 Jul 1;3(7):e2016485.

doi: 10.1001/jamanetworkopen.2020.16485.

Authors

Pierre Francois Laterre¹, Bruno François², Christine Collienne¹, Philippe Hantson¹, Robin Jeannet³, Kenneth E Remy^{4

5

6}, Richard S Hotchkiss^{5

6

7}

Affiliations

¹ Department of Critical Care Medicine, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
² Intensive Care Unit Department and Inserm Centre Investigation Clinique 1435 and Unité Mixte de Recherche 1092, University Hospital of Limoges, Limoges, France.
³ Department of Intensive Care Medicine and Anaesthesiology, University Hospital of Limoges, Limoges, France.
⁴ Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁵ Department of Anesthesiology and Critical Care Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁶ Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
⁷ Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri.

PMID: 32697322
PMCID: PMC7376391
DOI: 10.1001/jamanetworkopen.2020.16485

Abstract

This case series examines whether interleukin 7 (IL-7) is associated with restored host protective immunity in patients with severe coronavirus disease 2019 (COVID-19) and immunosuppression.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Hotchkiss reported being an investigator on a sepsis study evaluating interleukin 7 and receiving grants from the National Institutes of Health outside the submitted work. No other disclosures were reported.

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References

1. Vardhana SA, Wolchok JD. The many faces of the anti-COVID immune response. J Exp Med. 2020;217(6):217. doi:10.1084/jem.20200678 - DOI - PMC - PubMed
1. Menter T, Haslbauer JD, Nienhold R, et al. . Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction. Histopathology. Published May 4, 2020. doi:10.1111/his.14134 - DOI - PMC - PubMed
1. Wang D, Hu B, Hu C, et al. . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585 - DOI - PMC - PubMed
1. Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol. 2011;11(5):330-342. doi:10.1038/nri2970 - DOI - PMC - PubMed
1. Barata JT, Durum SK, Seddon B. Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 2019;20(12):1584-1593. doi:10.1038/s41590-019-0479-x - DOI - PubMed

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[1] Vardhana SA, Wolchok JD. The many faces of the anti-COVID immune response. J Exp Med. 2020;217(6):217. doi:10.1084/jem.20200678 - DOI - PMC - PubMed

[2] Vardhana SA, Wolchok JD. The many faces of the anti-COVID immune response. J Exp Med. 2020;217(6):217. doi:10.1084/jem.20200678 - DOI - PMC - PubMed

[3] Menter T, Haslbauer JD, Nienhold R, et al. . Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction. Histopathology. Published May 4, 2020. doi:10.1111/his.14134 - DOI - PMC - PubMed

[4] Menter T, Haslbauer JD, Nienhold R, et al. . Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction. Histopathology. Published May 4, 2020. doi:10.1111/his.14134 - DOI - PMC - PubMed

[5] Wang D, Hu B, Hu C, et al. . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585 - DOI - PMC - PubMed

[6] Wang D, Hu B, Hu C, et al. . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585 - DOI - PMC - PubMed

[7] Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol. 2011;11(5):330-342. doi:10.1038/nri2970 - DOI - PMC - PubMed

[8] Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol. 2011;11(5):330-342. doi:10.1038/nri2970 - DOI - PMC - PubMed

[9] Barata JT, Durum SK, Seddon B. Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 2019;20(12):1584-1593. doi:10.1038/s41590-019-0479-x - DOI - PubMed

[10] Barata JT, Durum SK, Seddon B. Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 2019;20(12):1584-1593. doi:10.1038/s41590-019-0479-x - DOI - PubMed

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Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

Affiliations

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

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