Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

Cell. 2020 Aug 20;182(4):794-795. doi: 10.1016/j.cell.2020.06.040. Epub 2020 Jul 3.

Abstract

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.

Publication types

  • Comment

MeSH terms

  • Betacoronavirus*
  • Coronavirus Infections*
  • Humans
  • Mutation
  • Pandemics*
  • Pneumonia, Viral*

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2