The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study

Cardiovasc Res. 2020 Dec 1;116(14):2185-2196. doi: 10.1093/cvr/cvaa209.


Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear.

Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation.

Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.

Clinical trial registration: identifier NCT04403607.

Keywords: Biomarkers; Imaging; Myocardial infarction; Myocardial inflammation; Myocardial injury; SARS-CoV-2.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • COVID-19 / diagnostic imaging*
  • COVID-19 / therapy
  • COVID-19 / virology
  • Convalescence
  • Electrocardiography
  • Heart / diagnostic imaging*
  • Heart / virology
  • Heart Diseases / diagnostic imaging*
  • Heart Diseases / virology
  • Host-Pathogen Interactions
  • Humans
  • Kidney / diagnostic imaging*
  • Kidney / virology
  • Kidney Diseases / diagnostic imaging*
  • Kidney Diseases / virology
  • Longitudinal Studies
  • Lung / diagnostic imaging*
  • Lung / virology
  • Multimodal Imaging*
  • Predictive Value of Tests
  • Prospective Studies
  • Research Design
  • SARS-CoV-2 / pathogenicity
  • Scotland
  • Time Factors

Associated data