Relationship between periodontal disease and male infertility: A case-control study

Oral Dis. 2021 Apr;27(3):624-631. doi: 10.1111/odi.13552. Epub 2020 Aug 31.


Objectives: To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study.

Materials and methods: Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities were included in the case group. The control group was composed of patients of the same clinic with normozoospermia. The semen analysis included sperm concentration, count and progressive and total motility, which were measured in the laboratory. A questionnaire and clinical periodontal examination were conducted for all participants. Logistic regression was performed to explore the relationship between chronic periodontitis and male infertility.

Results: A total of 192 participants were included: 63 participants (32.8%) had some type of semen abnormality (case group), while 129 participants (67.2%) had normozoospermia (control group). The case group had a significantly higher prevalence of moderate/severe periodontitis than the control group (33.3% vs. 17.8%, p = .012). The logistic regression showed that participants who had moderate/severe periodontitis had a greater chance of having semen abnormalities after adjusting for other confounding factors (OR = 3.377, p = .005).

Conclusions: Periodontitis is associated with semen abnormalities and sperm motility in men.

Keywords: chronic periodontitis; male infertility; sperm motility.

MeSH terms

  • Case-Control Studies
  • Humans
  • Infertility, Male* / epidemiology
  • Male
  • Periodontal Diseases*
  • Sperm Count
  • Sperm Motility