Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study

Tushar K Das; Jyothika Kumar; Susan Francis; Peter F Liddle; Lena Palaniyappan

doi:10.1016/j.pscychresns.2020.111139

Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study

Psychiatry Res Neuroimaging. 2020 Sep 30:303:111139. doi: 10.1016/j.pscychresns.2020.111139. Epub 2020 Jul 15.

Authors

Tushar K Das¹, Jyothika Kumar², Susan Francis³, Peter F Liddle⁴, Lena Palaniyappan⁵

Affiliations

¹ Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
² Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, United Kingdom; Precision Imaging Beacon, University of Nottingham, Nottingham, United Kingdom.
³ Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom.
⁴ Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, United Kingdom.
⁵ Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada. Electronic address: lpalaniy@uwo.ca.

PMID: 32707490
DOI: 10.1016/j.pscychresns.2020.111139

Abstract

Given the emerging evidence in support of parietal brain stimulation to treat speech disorder in psychosis, we investigated structural and functional parietal dysconnectivity in schizophrenia (n = 34) and bipolar disorder with psychotic symptoms (n = 16). We found that both patient groups demonstrated reduced left parietal structural connectivity compared to healthy controls (n = 32). The three groups also differed significantly on the variability of left and right parietal dynamic functional connectivity. In patients with schizophrenia, parietal dysconnectivity predicted the severity of disorganisation symptoms. These findings suggest that dysconnectivity between the parietal lobe and the rest of the brain plays a key role in disorganisation symptoms of schizophrenia.

Keywords: Dynamic functional connectivity; Psychosis; Structural connectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bipolar Disorder / diagnostic imaging*
Bipolar Disorder / physiopathology
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Nerve Net / diagnostic imaging*
Nerve Net / physiopathology
Parietal Lobe / diagnostic imaging*
Parietal Lobe / physiopathology
Psychotic Disorders / diagnostic imaging*
Psychotic Disorders / physiopathology
Schizophrenia / diagnostic imaging
Schizophrenia / physiopathology
Schizophrenia, Disorganized / diagnostic imaging*
Schizophrenia, Disorganized / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding