Dysfunctional T Cell Mitochondria Lead to Premature Aging

Trends Mol Med. 2020 Sep;26(9):799-800. doi: 10.1016/j.molmed.2020.07.001. Epub 2020 Jul 22.

Abstract

Desdín-Micó et al. have shown that Tfam specific knockout in mouse T cells disrupts mitochondrial genome integrity and induces a burst of inflammatory cytokines and tumor necrosis factor (TNF)-α production, resulting in increased senescence, neuromuscular and vascular dysfunction, and molecular features that recapitulate premature aging. Interestingly, treatment with nicotinamide riboside (NR) alleviates this phenotype by reducing senescence and systemic inflammation.

Keywords: T cells; cytokine; mitochondria; premature aging; senescence.

Publication types

  • Comment

MeSH terms

  • Aging, Premature* / genetics
  • Animals
  • Humans
  • Inflammation
  • Mice
  • Mitochondria
  • Multimorbidity*
  • T-Lymphocytes