Children and COVID-19: Microbiological and immunological insights

Pediatr Pulmonol. 2020 Oct;55(10):2547-2555. doi: 10.1002/ppul.24978. Epub 2020 Jul 30.


Since its first description in China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide being declared a pandemic by the World Health Organization. More than 10.3 million people have been infected and more than 506 000 people died. However, SARS-CoV-2 had a lower impact on the pediatric population. Only about 1% to 2% of infected people are children and few deaths under the age of 14 are described so far. In this article, we discuss microbiological and immunological characteristics of SARS-CoV-2 infection in children highlighting the main differences from adult SARS-CoV-2 infection.

Keywords: COVID-19; SARS-CoV-2; children; immunology; novel coronavirus.

Publication types

  • Review

MeSH terms

  • Animals
  • COVID-19 / immunology*
  • COVID-19 / microbiology*
  • Carrier State
  • Child
  • Host-Pathogen Interactions
  • Humans
  • Microbiota
  • SARS-CoV-2* / physiology