Presentation of Severe Acute Respiratory Syndrome-Coronavirus 2 Infection as Cholestatic Jaundice in Two Healthy Adolescents

J Pediatr. 2020 Nov;226:278-280. doi: 10.1016/j.jpeds.2020.07.054. Epub 2020 Jul 23.


Liver abnormalities in severe acute respiratory syndrome-coronavirus 2 infection, including hepatitis and cholestasis, have been observed in adults and are associated with worse outcomes. We describe 2 adolescents with cholestasis and hepatitis with mild presentation of severe acute respiratory syndrome-coronavirus 2 lacking typical symptoms. Our intention is to raise index of suspicion for testing and protective equipment use.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • COVID-19 / complications
  • COVID-19 / diagnosis*
  • COVID-19 Testing*
  • Female
  • Hepatitis, Viral, Human / diagnosis
  • Hepatitis, Viral, Human / virology*
  • Humans
  • Jaundice, Obstructive / diagnosis
  • Jaundice, Obstructive / virology*
  • Male
  • Severity of Illness Index