The importance of intracellular bacterial biofilm in infectious diseases

Microb Pathog. 2020 Oct:147:104393. doi: 10.1016/j.micpath.2020.104393. Epub 2020 Jul 22.

Abstract

Various bacterial species, previously known as extracellular pathogens, can reside inside different host cells by adapting to intracellular modes by forming microbial aggregates with similar characteristics to bacterial biofilms. Additionally, bacterial invasion of human cells leads to failure in antibiotic therapy, as most conventional anti-bacterial agents cannot reach intracellular biofilm in normal concentrations. Various studies have shown that bacteria such as uropathogenic Escherichia coli, Pseudomonas aeruginosa, Borrelia burgdorferi,Moraxella catarrhalis, non-typeable Haemophilus influenzae, Streptococcus pneumonia, and group A Streptococci produce biofilm-like structures within the host cells. For the first time in this review, we will describe and discuss the new information about intracellular bacterial biofilm formation and its importance in bacterial infectious diseases.

Keywords: Alzheimer's disease; Biofilm; Chronic tonsillitis; Intracellular biofilm; Lung infections; Otitis media; Pseudomonas aeruginosa; Psoriasis; Uropathogenic Escherichia coli.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Biofilms*
  • Communicable Diseases*
  • Haemophilus Infections*
  • Haemophilus influenzae
  • Humans
  • Moraxella catarrhalis

Substances

  • Anti-Bacterial Agents