Physiological relevance of food antioxidants

Adv Food Nutr Res. 2020:93:205-250. doi: 10.1016/bs.afnr.2020.03.002. Epub 2020 Apr 3.


Dietary antioxidants are associated with prevention of oxidative stress related chronic diseases including certain types of cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. In recent years, there has been a growing interest in extending the knowledge on their physiological effects in human body. There are numbers of epidemiological, clinical, meta-analysis, and in vitro studies to explain formation mechanisms of each chronic diseases as well as the potential effects of dietary antioxidants on these diseases and gut health. Comprehensive studies for food antioxidants' journey from dietary intake to target tissues/organs deserve a serious consideration to have a clear understanding on the physiological effects of dietary antioxidants. Therefore, absorption and metabolism of dietary antioxidants, and the factors affecting their absorption, such as solubility of antioxidants, food matrix, and interaction between antioxidants have been evaluated in several research articles. This chapter provides an overview about potential health effects of dietary antioxidants considering with their absorption and metabolism in human body.

Keywords: Bioavailability; Chronic diseases; Dietary antioxidants; Physiological effects.

Publication types

  • Review

MeSH terms

  • Antioxidants / metabolism
  • Antioxidants / pharmacokinetics
  • Antioxidants / pharmacology*
  • Biological Availability
  • Cardiovascular Diseases / metabolism
  • Diabetes Mellitus / metabolism
  • Diet*
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / metabolism
  • Humans
  • Neoplasms / metabolism
  • Neurodegenerative Diseases / metabolism
  • Oxidative Stress / drug effects*
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacokinetics
  • Plant Extracts / pharmacology*
  • Plants, Edible / chemistry*


  • Antioxidants
  • Plant Extracts