Antisynthetase syndrome in pregnancy: A case and review of the literature

Obstet Med. 2020 Jun;13(2):96-100. doi: 10.1177/1753495X18808646. Epub 2018 Nov 8.


Antisynthetase syndrome is a rare autoimmune, multisystem, inflammatory condition, characterised by autoantibodies against aminoacyl tRNA synthetases. The predominant features are myositis and interstitial lung disease but other symptoms such as Raynaud's phenomenon may also be present. Described here is a 36-year-old woman with antisynthetase syndrome who planned and underwent a successful pregnancy, during which a multidisciplinary team approach secured a good outcome for both mother and baby.

Keywords: Antisynthetase syndrome; anti-Ro antibodies; inflammatory myopathy; pregnancy.

Publication types

  • Case Reports