[Studies on the question of a possible autoregulation of insulin secretion (author's transl)]

Klin Wochenschr. 1977 May 15;55(10):475-9. doi: 10.1007/BF01489005.
[Article in German]


In eight normal weight healthy volunteers it was proved by C-peptide assay whether high concentrations of insulin in serum would suppress the secretion of insulin in an autoregulative manner. Insulin combined with glucose, therefore was given intravenously as a single bolus injection as well as an infusion over a period of two hours. Moreover it was proved whether high levels of insulin would suppress the reactivity of the B-cell to sulphonylurea administration. It was demonstrated that the secretion of the B-cell is regulated only by the concentration of the blood sugar, but not by the level of serum insulin. Likewise the stimulation of the B-cell by sulphonyl-urea administration is not suppressed by high concentrations of insulin.

MeSH terms

  • Blood Glucose
  • C-Peptide / blood
  • Depression, Chemical
  • Drug Combinations
  • Glucose / administration & dosage
  • Glucose / pharmacology
  • Homeostasis
  • Humans
  • Insulin / administration & dosage
  • Insulin / metabolism*
  • Insulin / pharmacology
  • Insulin Secretion
  • Islets of Langerhans / drug effects
  • Sulfonylurea Compounds / administration & dosage
  • Sulfonylurea Compounds / pharmacology


  • Blood Glucose
  • C-Peptide
  • Drug Combinations
  • Insulin
  • Sulfonylurea Compounds
  • Glucose