Prognostic factors in the hemolytic-uremic syndrome

Child Nephrol Urol. 1988-1989;9(5):264-8.

Abstract

During 1972-1986, 142 children with the hemolytic-uremic syndrome were treated. Most of them were infants (73%). The total mortality rate reached 25.4%. Computer analysis revealed the following risk factors of a fatal outcome: severe gastrointestinal symptoms during the prodromal period, coma, convulsions, malignant hypertension, persistence of prodromal symptoms over 7 days, hyperkalemia over 7 mmol/l, acidosis with bicarbonate level less than 15 mmol/l, a delay of over 5 days in starting dialysis, and transport to dialysis unit of over 100 km. The greatest risk of death existed during the first 3 weeks from onset. Among 142 children, 106 survived the acute phase. They were followed up from 2 to 16 years. Nine were lost to follow-up. Twelve children developed chronic renal failure.

MeSH terms

  • Discriminant Analysis
  • Female
  • Follow-Up Studies
  • Hemolytic-Uremic Syndrome / mortality*
  • Humans
  • Infant
  • Kidney Failure, Chronic / epidemiology
  • Life Tables
  • Male
  • Prognosis
  • Risk Factors
  • Time Factors