Procalcitonin as an antibiotic stewardship tool in COVID-19 patients in the intensive care unit

doi:10.1016/j.jgar.2020.07.017

. 2020 Sep:22:782-784.

doi: 10.1016/j.jgar.2020.07.017. Epub 2020 Jul 25.

Procalcitonin as an antibiotic stewardship tool in COVID-19 patients in the intensive care unit

Lesley Heesom¹, Lucas Rehnberg¹, Myra Nasim-Mohi¹, Alexander I R Jackson², Michael Celinski¹, Ahilanadan Dushianthan¹, Paul Cook³, William Rivinberg³, Kordo Saeed⁴

Affiliations

¹ General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, Tremona Road, Southampton, UK.
² General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, Tremona Road, Southampton, UK; Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
³ Department of Biochemistry University Hospital Southampton NHS Foundation Trust, University of Southampton School of Medicine, Southampton, UK.
⁴ Microbiology Innovation and Research Unit (MIRU), Department of Microbiology, University Hospitals Southampton NHS Foundation Trust, and University of Southampton School of Medicine, Southampton, UK; International Society of Antimicrobial Chemotherapy (ISAC), Chair of Rapid Diagnostics and Biomarker Working Group. Electronic address: Kordo.Saeed@uhs.nhs.uk.

PMID: 32717489
PMCID: PMC7381395
DOI: 10.1016/j.jgar.2020.07.017

Procalcitonin as an antibiotic stewardship tool in COVID-19 patients in the intensive care unit

Lesley Heesom et al. J Glob Antimicrob Resist. 2020 Sep.

. 2020 Sep:22:782-784.

doi: 10.1016/j.jgar.2020.07.017. Epub 2020 Jul 25.

Authors

Lesley Heesom¹, Lucas Rehnberg¹, Myra Nasim-Mohi¹, Alexander I R Jackson², Michael Celinski¹, Ahilanadan Dushianthan¹, Paul Cook³, William Rivinberg³, Kordo Saeed⁴

Affiliations

¹ General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, Tremona Road, Southampton, UK.
² General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, Tremona Road, Southampton, UK; Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
³ Department of Biochemistry University Hospital Southampton NHS Foundation Trust, University of Southampton School of Medicine, Southampton, UK.
⁴ Microbiology Innovation and Research Unit (MIRU), Department of Microbiology, University Hospitals Southampton NHS Foundation Trust, and University of Southampton School of Medicine, Southampton, UK; International Society of Antimicrobial Chemotherapy (ISAC), Chair of Rapid Diagnostics and Biomarker Working Group. Electronic address: Kordo.Saeed@uhs.nhs.uk.

PMID: 32717489
PMCID: PMC7381395
DOI: 10.1016/j.jgar.2020.07.017

No abstract available

Keywords: Antibiotic stewardship; COVID-19; PCT; Procalcitonin; SARS-CoV-2.

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Comment in

Interpreting serum procalcitonin in COVID-19 patients undergoing renal replacement therapy.
Adams B, Beaney A. Adams B, et al. J Glob Antimicrob Resist. 2021 Dec;27:324-325. doi: 10.1016/j.jgar.2021.09.014. Epub 2021 Nov 12. J Glob Antimicrob Resist. 2021. PMID: 34775132 Free PMC article. No abstract available.

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C-reactive protein-guided use of procalcitonin in COVID-19.
Houghton R, Moore N, Williams R, El-Bakri F, Peters J, Mori M, Vernet G, Lynch J, Lewis H, Tavener M, Durham T, Bowyer J, Saeed K, Pollara G. Houghton R, et al. JAC Antimicrob Resist. 2021 Nov 28;3(4):dlab180. doi: 10.1093/jacamr/dlab180. eCollection 2021 Dec. JAC Antimicrob Resist. 2021. PMID: 34859223 Free PMC article.
Procalcitonin Evaluation of Antibiotic Use in COVID-19 Hospitalised Patients (PEACH): Protocol for a Retrospective Observational Study.
Euden J, Pallmann P, Grozeva D, Albur M, Bond SE, Brookes-Howell L, Dark P, Hellyer T, Hopkins S, Howard P, Llewelyn MJ, Maboshe W, McCullagh IJ, Ogden M, Parsons H, Partridge D, Powell N, Shaw D, Shinkins B, Szakmany T, Todd S, Thomas-Jones E, West RM, Carrol ED, Sandoe JAT; PEACH Study Group. Euden J, et al. Methods Protoc. 2022 Nov 28;5(6):95. doi: 10.3390/mps5060095. Methods Protoc. 2022. PMID: 36548137 Free PMC article.
Implications of COVID-19 Pandemic on the Emergence of Antimicrobial Resistance: Adjusting the Response to Future Outbreaks.
Rusic D, Vilovic M, Bukic J, Leskur D, Seselja Perisin A, Kumric M, Martinovic D, Petric A, Modun D, Bozic J. Rusic D, et al. Life (Basel). 2021 Mar 10;11(3):220. doi: 10.3390/life11030220. Life (Basel). 2021. PMID: 33801799 Free PMC article. Review.
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Atallah NJ, Warren HM, Roberts MB, Elshaboury RH, Bidell MR, Gandhi RG, Adamsick M, Ibrahim MK, Sood R, Bou Zein Eddine S, Cobler-Lichter MJ, Alexander NJ, Timmer KD, Atallah CJ, Viens AL, Panossian VS, Scherer AK, Proctor T, Smartt S, Letourneau AR, Paras ML, Johannes S, Wiemer J, Mansour MK. Atallah NJ, et al. PLoS One. 2022 Jan 13;17(1):e0262342. doi: 10.1371/journal.pone.0262342. eCollection 2022. PLoS One. 2022. PMID: 35025929 Free PMC article.

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References

1. Gautret P., Lagier J.-C., Parola P., Hoang V.T., Meddeb L., Mailhe M. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020:105949. doi: 10.1016/j.ijantimicag.2020.105949. - DOI - PMC - PubMed
1. National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital. NICE n.d. https://www.nice.org.uk/guidance/ng173/chapter/tests-to-guide-decisions-... [accessed 22.05.20]. - PubMed
1. Schuetz P., Beishuizen A., Broyles M., Ferrer R., Gavazzi G., Gluck E.H. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med. 2019 doi: 10.1515/cclm-2018-1181. - DOI - PubMed
1. Zheng Z., Peng F.B., Xu B., Zhao J., Liu H., Peng J. Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis. J Infect. 2020 doi: 10.1016/j.jinf.2020.04.021. - DOI - PMC - PubMed

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[1] Gautret P., Lagier J.-C., Parola P., Hoang V.T., Meddeb L., Mailhe M. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020:105949. doi: 10.1016/j.ijantimicag.2020.105949. - DOI - PMC - PubMed

[2] Gautret P., Lagier J.-C., Parola P., Hoang V.T., Meddeb L., Mailhe M. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020:105949. doi: 10.1016/j.ijantimicag.2020.105949. - DOI - PMC - PubMed

[3] National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital. NICE n.d. https://www.nice.org.uk/guidance/ng173/chapter/tests-to-guide-decisions-... [accessed 22.05.20]. - PubMed

[4] National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital. NICE n.d. https://www.nice.org.uk/guidance/ng173/chapter/tests-to-guide-decisions-... [accessed 22.05.20]. - PubMed

[5] Schuetz P., Beishuizen A., Broyles M., Ferrer R., Gavazzi G., Gluck E.H. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med. 2019 doi: 10.1515/cclm-2018-1181. - DOI - PubMed

[6] Schuetz P., Beishuizen A., Broyles M., Ferrer R., Gavazzi G., Gluck E.H. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med. 2019 doi: 10.1515/cclm-2018-1181. - DOI - PubMed

[7] Zheng Z., Peng F.B., Xu B., Zhao J., Liu H., Peng J. Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis. J Infect. 2020 doi: 10.1016/j.jinf.2020.04.021. - DOI - PMC - PubMed

[8] Zheng Z., Peng F.B., Xu B., Zhao J., Liu H., Peng J. Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis. J Infect. 2020 doi: 10.1016/j.jinf.2020.04.021. - DOI - PMC - PubMed

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Procalcitonin as an antibiotic stewardship tool in COVID-19 patients in the intensive care unit

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