Insights into the Effects of Mesenchymal Stem Cell-Derived Secretome in Parkinson's Disease

Int J Mol Sci. 2020 Jul 23;21(15):5241. doi: 10.3390/ijms21155241.

Abstract

Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like those reported after MSCs transplantation. MSC-derived secretome may avoid various side effects of MSC-based therapy, comprising undesirable differentiation of engrafted MSCs and potential activation of the allogeneic immune response. MSC-derived secretome comprises soluble factors and encapsulated extravesicles (EVs). MSC-derived EVs comprise microvesicles, apoptotic bodies, and exosomes. In this review, we focus on the recent insights into the effects of MSC-derived secretome in Parkinson's disease (PD). In particular, MSC-derived secretome and exosomal components counteracted neuroinflammation and enhanced antioxidant capacity and neurotrophic factors expression. In light of the insights reported in this review, MSC-derived secretome or their released exosomes may be used as a potential therapeutic approach or as adjuvant therapy to counteract the disease progression and improve PD symptoms. Also, MSC-derived secretome may be used as a vehicle in cell transplantation approaches to enhance the viability and survival of engrafted cells. Furthermore, since exosomes can cross the blood-brain barrier, they may be used as biomarkers of neural dysfunction. Further studies are necessary to fully characterize the bioactive molecules present in the secretome and to create a new, effective, cell-free therapeutic approach towards a robust clinical outcome for PD patients.

Keywords: Parkinson’s disease; conditioned medium; exosomes; extravesicles; mesenchymal stem cells; secretome; stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood-Brain Barrier* / metabolism
  • Blood-Brain Barrier* / pathology
  • Cell Differentiation*
  • Disease Models, Animal
  • Exosomes* / metabolism
  • Exosomes* / pathology
  • Exosomes* / transplantation
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / metabolism
  • Mesenchymal Stem Cells / pathology
  • Parkinson Disease* / metabolism
  • Parkinson Disease* / pathology
  • Parkinson Disease* / therapy