Cerebrospinal Fluid Testing for Multiple Sclerosis

Joshua F Goldsmith; A Zara Herskovits

doi:10.1016/j.cll.2020.06.002

Cerebrospinal Fluid Testing for Multiple Sclerosis

Clin Lab Med. 2020 Sep;40(3):369-377. doi: 10.1016/j.cll.2020.06.002. Epub 2020 Jul 2.

Authors

Joshua F Goldsmith¹, A Zara Herskovits²

Affiliations

¹ Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
² Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: aherskov@bidmc.harvard.edu.

PMID: 32718506
DOI: 10.1016/j.cll.2020.06.002

Abstract

Multiple sclerosis is one of the most common autoimmune diseases affecting the central nervous system. Current guidelines characterize multiple sclerosis and related conditions based on clinical, imaging, and body fluid markers. In this review, we describe how laboratory analysis of cerebrospinal fluid is currently performed and discuss new approaches under development for multiple sclerosis diagnostics.

Keywords: Autoimmune disease; Biomarkers; Cerebrospinal fluid; Isoelectric focusing; Multiple sclerosis.

Publication types

Review

MeSH terms

Biomarkers / blood
Biomarkers / cerebrospinal fluid
Humans
Immunoglobulin G / blood
Immunoglobulin G / cerebrospinal fluid
Isoelectric Focusing
Multiple Sclerosis / blood
Multiple Sclerosis / cerebrospinal fluid*
Multiple Sclerosis / diagnosis*

Substances

Biomarkers
Immunoglobulin G