Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China

Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00904-20. doi: 10.1128/AAC.00904-20. Print 2020 Sep 21.

Abstract

A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples.

Keywords: Aspergillus fumigatus; G448S; environmental resistance; microsatellite typing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology
  • Aspergillus fumigatus* / genetics
  • Azoles / pharmacology
  • China
  • Drug Resistance, Fungal* / genetics
  • Fungal Proteins / genetics
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • Azoles
  • Fungal Proteins