Neurodevelopmental insights into circuit dysconnectivity in schizophrenia

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110047. doi: 10.1016/j.pnpbp.2020.110047. Epub 2020 Jul 25.


Schizophrenia is increasingly being recognized as a disorder of brain circuits of developmental origin. Animal models, however, have been technically limited in exploring the effects of early developmental circuit abnormalities on the maturation of the brain and associated behavioural outputs. This review discusses evidence of the developmental emergence of circuit abnormalities in schizophrenia, followed by a critical assessment on how animal models need to be adapted through optimized tools in order to spatially and temporally manipulate early developmental events, thereby providing insight into the causal contribution of developmental perturbations to schizophrenia.

Keywords: Circuit; Development; Dysconnectivity; Schizophrenia.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / physiopathology*
  • Disease Models, Animal
  • Humans
  • Nerve Net / physiopathology*
  • Neural Pathways / physiopathology
  • Schizophrenia / physiopathology*