Palmitoylation: A new mechanism for control of NCX1 function

Cell Calcium. 2020 Nov;91:102254. doi: 10.1016/j.ceca.2020.102254. Epub 2020 Jul 17.


A paper by Gök et al., identified Zinc Finger DHHC-Type Palmitoyltransferase 5 (zDHHC5) and Acyl-Protein Transferase 1 (APT1) as the enzymes responsible for the dynamic palmitoylation of NCX1. Palmitoylation occurs at the cell surface and increases the affinity of NCX1 for lipid rafts. Additionally, they discovered that palmitoylation controls the affinity of NCX1 for exchange inhibitory protein (XIP) and regulates intracellular calcium concentration. These findings provide new insights into endogenous control of NCX1 function and will drive future investigations directed at understanding its full potential.

Keywords: APT1; NCX1; Palmitoylation; zDHHC5.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Humans
  • Lipoylation*
  • Models, Biological
  • Sodium-Calcium Exchanger / metabolism*


  • Sodium-Calcium Exchanger
  • sodium-calcium exchanger 1
  • Calcium