Sensitization to Gibberellin-Regulated Protein (Peamaclein) Among Italian Cypress Pollen-Sensitized Patients

J Investig Allergol Clin Immunol. 2021 Feb 21;32(1):40-47. doi: 10.18176/jiaci.0542. Epub 2021 Jul 30.


Background and objectives: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food allergen in cypress pollen-hypersensitive patients. Objective: We investigated monosensitization to peamaclein among Italian cypress pollen-allergic patients.

Material and methods: A total of 835 cypress pollen-hypersensitive patients from 28 Italian allergy centers underwent a thorough work-up to determine food-allergic reactions and performed skin prick testing with a commercial peach extract containing peamaclein. IgE to rPru p 3 was measured in peach reactors, and those with negative results were enrolled as potentially monosensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated using immunoblot and an experimental ImmunoCAP with rPru p 7.

Results: Skin prick tests were positive to peach in 163 patients (19.5%); however, 127 (77.9%) were excluded because they reacted to Pru p 3. Twenty-four patients (14.7%) corresponding to 2.8% of the entire study population) were considered potentially monosensitized to peamaclein. No geographic preference was observed. Seventeen of the 24 patients (70.8%) had a history of food allergy, mainly to peach (n=15). Additional offending foods included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3 of 18 putative peamaclein-allergic patients reacted to a band at about 7 kDa; an additional 4 patients reacted at about 50-60 kDa. Ten of 18 patients (56%) had a positive result for Pru p 7 on ImmunoCAP.

Conclusion: Allergy and sensitization to peamaclein seem rare in Italy. Most patients react to peach, although other Rosaceae fruits and several citrus fruits may also be offending foods. Peach and cypress pollen probably also share cross-reacting allergens other than peamaclein.

Keywords: Cypress pollen allergy; Food allergy; Peach; Peamaclein; Pollen-food syndrome.

MeSH terms

  • Allergens / adverse effects
  • Antigens, Plant / adverse effects
  • Cross Reactions
  • Cupressus*
  • Food Hypersensitivity* / epidemiology
  • Gibberellins
  • Humans
  • Immunoglobulin E
  • Plant Proteins / adverse effects
  • Pollen
  • Skin Tests / adverse effects


  • Allergens
  • Antigens, Plant
  • Gibberellins
  • Plant Proteins
  • Immunoglobulin E