Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic

QJM. 2021 Feb 18;114(1):3-10. doi: 10.1093/qjmed/hcaa234.


Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic.

Publication types

  • Review

MeSH terms

  • COVID-19* / epidemiology
  • COVID-19* / metabolism
  • COVID-19* / therapy
  • Dietary Supplements
  • Humans
  • SARS-CoV-2
  • Vitamin D Deficiency* / epidemiology
  • Vitamin D Deficiency* / therapy
  • Vitamin D* / metabolism
  • Vitamin D* / pharmacology
  • Vitamins / metabolism
  • Vitamins / pharmacology


  • Vitamins
  • Vitamin D