Blood Pressure Dynamics After Pubertal Suppression with Gonadotropin-Releasing Hormone Analogs Followed by Testosterone Treatment in Transgender Male Adolescents: A Pilot Study

LGBT Health. 2020 Aug/Sep;7(6):340-344. doi: 10.1089/lgbt.2020.0026. Epub 2020 Jul 28.


Purpose: We analyzed blood pressure (BP) changes in transgender male adolescents treated with gonadotropin-releasing hormone analogs (GnRHa) and after adding testosterone treatment. Methods: This was a retrospective pilot study. Outcome measures included systolic BP (SBP) and diastolic BP (DBP) before and after GnRHa initiation and after adding testosterone. Results: Fifteen transgender male adolescents received GnRHa. DBP percentiles increased significantly after GnRHa treatment (from 55.9% ± 26.4 to 73.6% ± 9.4, p = 0.019). BP levels did not meet criteria for hypertension. DBP percentiles were restored after adding testosterone. Conclusion: GnRHa may increase DBP in transgender male adolescents, and testosterone treatment may restore it. Further larger studies are indicated.

Keywords: blood pressure; gender dysphoria; gender-affirming hormone treatment; gonadotropin-releasing hormone analog; testosterone; transgender male adolescents.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Female
  • Gender Dysphoria / drug therapy*
  • Gonadotropin-Releasing Hormone / therapeutic use*
  • Humans
  • Male
  • Pilot Projects
  • Puberty
  • Retrospective Studies
  • Testosterone / therapeutic use*
  • Transgender Persons / statistics & numerical data*


  • Gonadotropin-Releasing Hormone
  • Testosterone