Risk of seizures with antidepressants: what is the evidence?

Drug Ther Bull. 2020 Sep;58(9):137-140. doi: 10.1136/dtb.2019.000044. Epub 2020 Jul 31.

Abstract

Topics for DTB review articles are selected by DTB's editorial board to provide concise overviews of medicines and other treatments to help patients get the best care. Articles include a summary of key points and a brief overview for patients. Articles may also have a series of multiple choice CME questions.

Keywords: Depression; Drug safety; Epilepsy and other seizure disorders.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / therapeutic use
  • Antidepressive Agents / adverse effects*
  • Antidepressive Agents / metabolism
  • Antidepressive Agents / therapeutic use*
  • Depression / complications
  • Depression / drug therapy
  • Depressive Disorder / complications
  • Depressive Disorder / drug therapy
  • Epilepsy / chemically induced
  • Epilepsy / drug therapy
  • Humans
  • Risk Factors
  • Seizures / chemically induced*
  • Seizures / drug therapy

Substances

  • Anticonvulsants
  • Antidepressive Agents