The 24-h rotational period of the earth has driven evolution of biological systems that serve to synchronize organismal physiology and behavior to this predictable environmental event. In mammals, the circadian (circa, "about" and dia, "a day") clock keeps 24-h time at the organismal and cellular level, optimizing biological function for a given time of day. The most obvious circadian output is the sleep-wake cycle, though countless bodily functions, ranging from hormone levels to cognitive function, are influenced by the circadian clock. Here we discuss the regulation of metabolic pathways by the circadian clock, discuss the evidence implicating circadian and sleep disruption in neurodegenerative diseases, and suggest some possible connections between the clock, metabolism, and neurodegenerative disease.
Keywords: Alzheimer's disease (AD); Circadian rhythms; Clocks; Huntington's disease (HD); Metabolism; Mitochondria; NAD(+); Neurodegeneration; Parkinson's disease (PD); Sirtuins; Sleep disorders; Suprachiasmatic nucleus (SCN).
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