Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis

Curr Opin Struct Biol. 2020 Dec:65:159-167. doi: 10.1016/j.sbi.2020.06.015. Epub 2020 Jul 30.


Allosteric regulation of the enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) controls the entry into aromatic amino acid biosynthesis in plants and microorganisms. DAH7PS has acquired a diverse range of allosteric machinery to enable this functionality. This review provides an overview of the current knowledge of the structural basis of allostery in this enzyme family and the evolutionary relationships between the different solutions to allosteric control of aromatic metabolite biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3-Deoxy-7-Phosphoheptulonate Synthase* / chemistry
  • 3-Deoxy-7-Phosphoheptulonate Synthase* / metabolism
  • Allosteric Regulation
  • Bacteria / enzymology
  • Bacterial Proteins* / chemistry
  • Bacterial Proteins* / metabolism
  • Plant Proteins* / chemistry
  • Plant Proteins* / metabolism
  • Plants / enzymology


  • Bacterial Proteins
  • Plant Proteins
  • 3-Deoxy-7-Phosphoheptulonate Synthase