Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study

doi:10.1097/CEJ.0000000000000569

. 2020 Sep;29(5):445-451.

doi: 10.1097/CEJ.0000000000000569.

Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study

Fu-Zong Wu^{1

2

3}, Yi-Luan Huang^{1

2

3}, Yun-Ju Wu¹, En-Kuei Tang^{4

5}, Ming-Ting Wu^{1

2

3}, Chi-Shen Chen⁶, Yun-Pei Lin^{1

2

3}

Affiliations

¹ Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
² Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan.
³ Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan.
⁴ Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
⁵ Department of Nursing, Shu-Zen Junior College of Medicine and Management.
⁶ Physical Examination Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

PMID: 32740170
DOI: 10.1097/CEJ.0000000000000569

Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study

Fu-Zong Wu et al. Eur J Cancer Prev. 2020 Sep.

. 2020 Sep;29(5):445-451.

doi: 10.1097/CEJ.0000000000000569.

Authors

Fu-Zong Wu^{1

2

3}, Yi-Luan Huang^{1

2

3}, Yun-Ju Wu¹, En-Kuei Tang^{4

5}, Ming-Ting Wu^{1

2

3}, Chi-Shen Chen⁶, Yun-Pei Lin^{1

2

3}

Affiliations

¹ Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
² Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan.
³ Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan.
⁴ Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
⁵ Department of Nursing, Shu-Zen Junior College of Medicine and Management.
⁶ Physical Examination Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

PMID: 32740170
DOI: 10.1097/CEJ.0000000000000569

Abstract

Low-dose computed tomography lung cancer screening aims to detect early-stage lung cancers in order to decrease the incidence of advanced-stage lung cancers and to reduce lung cancer mortality. We analyzed the time trends of lung cancer stage distribution and mortality rates after the gradual implementation of the low-dose computed tomography lung cancer screening in a hospital-based cohort. Using the hospital-based cancer registry data on lung cancer number and death from 2007 to 2014, we aim to evaluate the trends in stage distribution and mortality rate after the gradual implementation of low-dose computed tomography lung cancer screening program over recent years. From 2007 to 2014, overall 2542 cases of lung cancers were diagnosed according to hospital-based cancer registry. For the 1-year mortality rate, the mortality rate decreased gradually from 48.16 to 37.04% between 2007 and 2014. For the 5-year mortality rate, the mortality rate decreased gradually from 88.49 to 69.44% between 2007 and 2014. There was a gradual decrease in stage IV lung cancer with the corresponding sharp increase in stage I early lung cancer after following the implementation of the large volume of the low-dose computed tomography examination between the years 2011 and 2014. In conclusion, these results suggest that the gradual implementation of low-dose computed tomography lung screening program could lead to a remarkable decrease in lung cancer mortality and a remarkable stage shift in the trend over time in this hospital-based cohort.

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References

1. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365:395–409
1. Brenner AT, Malo TL, Margolis M, Elston Lafata J, James S, Vu MB, Reuland DS. Evaluating shared decision making for lung cancer screening. JAMA Intern Med. 2018; 178:1311–1316
1. Chang JS, Chen LT, Shan YS, Lin SF, Hsiao SY, Tsai CR, et al. Comprehensive analysis of the incidence and survival patterns of lung cancer by histologies, including rare subtypes, in the era of molecular medicine and targeted therapy: a nation-wide cancer registry-based study from Taiwan. Medicine. 2015; 94:e969–e969
1. Chen PA, Huang EP, Shih LY, Tang EK, Chien CC, Wu MT, Wu FZ. Qualitative CT criterion for subsolid nodule subclassification: improving interobserver agreement and pathologic correlation in the adenocarcinoma spectrum. Acad Radiol. 2018; 25:1439–1445
1. Detterbeck FC, Marom EM, Arenberg DA, Franklin WA, Nicholson AG, Travis WD, et al.; IASLC Staging and Prognostic Factors Committee; Advisory Boards; Multiple Pulmonary Sites Workgroup. The IASLC lung cancer staging project: background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 2016; 11:666–680

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[1] Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365:395–409

[2] Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365:395–409

[3] Brenner AT, Malo TL, Margolis M, Elston Lafata J, James S, Vu MB, Reuland DS. Evaluating shared decision making for lung cancer screening. JAMA Intern Med. 2018; 178:1311–1316

[4] Brenner AT, Malo TL, Margolis M, Elston Lafata J, James S, Vu MB, Reuland DS. Evaluating shared decision making for lung cancer screening. JAMA Intern Med. 2018; 178:1311–1316

[5] Chang JS, Chen LT, Shan YS, Lin SF, Hsiao SY, Tsai CR, et al. Comprehensive analysis of the incidence and survival patterns of lung cancer by histologies, including rare subtypes, in the era of molecular medicine and targeted therapy: a nation-wide cancer registry-based study from Taiwan. Medicine. 2015; 94:e969–e969

[6] Chang JS, Chen LT, Shan YS, Lin SF, Hsiao SY, Tsai CR, et al. Comprehensive analysis of the incidence and survival patterns of lung cancer by histologies, including rare subtypes, in the era of molecular medicine and targeted therapy: a nation-wide cancer registry-based study from Taiwan. Medicine. 2015; 94:e969–e969

[7] Chen PA, Huang EP, Shih LY, Tang EK, Chien CC, Wu MT, Wu FZ. Qualitative CT criterion for subsolid nodule subclassification: improving interobserver agreement and pathologic correlation in the adenocarcinoma spectrum. Acad Radiol. 2018; 25:1439–1445

[8] Chen PA, Huang EP, Shih LY, Tang EK, Chien CC, Wu MT, Wu FZ. Qualitative CT criterion for subsolid nodule subclassification: improving interobserver agreement and pathologic correlation in the adenocarcinoma spectrum. Acad Radiol. 2018; 25:1439–1445

[9] Detterbeck FC, Marom EM, Arenberg DA, Franklin WA, Nicholson AG, Travis WD, et al.; IASLC Staging and Prognostic Factors Committee; Advisory Boards; Multiple Pulmonary Sites Workgroup. The IASLC lung cancer staging project: background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 2016; 11:666–680

[10] Detterbeck FC, Marom EM, Arenberg DA, Franklin WA, Nicholson AG, Travis WD, et al.; IASLC Staging and Prognostic Factors Committee; Advisory Boards; Multiple Pulmonary Sites Workgroup. The IASLC lung cancer staging project: background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 2016; 11:666–680

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Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study

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Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study

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