Multiple Plantar Poromas in a Stem Cell Transplant Patient

Rachel L Marsh; Benjamin Kaffenberger; Llana Pootrakul; Catherine Chung

doi:10.7759/cureus.8773

Multiple Plantar Poromas in a Stem Cell Transplant Patient

Cureus. 2020 Jun 22;12(6):e8773. doi: 10.7759/cureus.8773.

Authors

Rachel L Marsh¹, Benjamin Kaffenberger², Llana Pootrakul², Catherine Chung³

Affiliations

¹ Dermatology, The Ohio State University College of Medicine, Columbus, USA.
² Dermatology, The Ohio State University Wexner Medical Center, Columbus, USA.
³ Division of Dermatology and Dermatopathology, The Ohio State University Wexner Medical Center, Columbus, USA.

Abstract

Poromatosis, or the formation of multiple eccrine poromas, is associated with chronic immunosuppression, lymphoproliferative neoplasms, and stem cell transplantation, though the etiology and clinical significance remain poorly understood. Eccrine poromas are asymptomatic, may appear years after treatment, and overlap morphologically with other diagnoses, particularly human papillomavirus-associated verrucae, to which immunosuppressed patients may be predisposed and commonly occur in similar sites. We report a 47-year-old female on chronic immunosuppression who developed multiple plantar eccrine poromas three years after achieving acute myeloid leukemia (AML) remission following treatment with chemotherapy, total body irradiation, and allogenic stem cell transplantation. We propose that early recognition, timely treatment, and regular follow-up skin examinations are necessary in the setting of multiple poromas to reduce the risk of malignancy and avoid delays in diagnosis.

Keywords: acute myeloid leukemia; chronic immunosuppression; eccrine poroma; graft versus host disease; lymphoproliferative neoplasm; multiple poromas; poromatosis; stem cell transplantation.

Publication types

Case Reports