Neoflavonoids from the heartwood of Dalbergia melanoxylon

Nat Prod Res. 2022 Feb;36(3):735-741. doi: 10.1080/14786419.2020.1800692. Epub 2020 Aug 3.


Three new neoflavonoids, named (1S,8R,9S)-1,5-dihydroxy-4,12-dimethoxy-8-vinyl-tricyclo[,7]trideca-2,4,6,11-tetraen-10-one (1), 2,5,2',5'-tetrahydroxy-4-methoxybenzophenone (2) and 2,5,3'-trihydroxy-4-methoxybenzophenone (3), were isolated from the heartwood of Dalbergia melanoxylon. Their structures were established by spectroscopic methods, including UV, IR, HRMS, 1 D and 2 D-NMR. Compounds 1-3 were evaluated for inhibitory activity against three fungal strains Candida albicans, Mucor ramosissimus, Saccharomycopsis fermentans and seven bacterial strains Shigella dysenteriae, Salmonella enteri, Bacillus cereus, Staphylococcus epidermidis, Bacillus sphaericus, Staphylococcus aureus, Escherichia coli using the broth dilution method. However, none of compounds 1-3 showed potential antimicrobial activities in vitro.

Keywords: Dalbergia melanoxylon; Neoflavonoid; antibacterial activity; antifungal activity.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Candida albicans
  • Dalbergia*
  • Escherichia coli
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Staphylococcus aureus


  • Anti-Bacterial Agents