The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database

Neuroimage. 2020 Nov 1;221:117200. doi: 10.1016/j.neuroimage.2020.117200. Epub 2020 Aug 1.


Normative databases allow testing of novel hypotheses without the costly collection of magnetic resonance imaging (MRI) data. Here we present the Amsterdam Ultra-high field adult lifespan database (AHEAD). The AHEAD consists of 105 7 Tesla (T) whole-brain structural MRI scans tailored specifically to imaging of the human subcortex, including both male and female participants and covering the entire adult life span (18-80 yrs). We used these data to create probability maps for the subthalamic nucleus, substantia nigra, internal and external segment of the globus pallidus, and the red nucleus. Data was acquired at a submillimeter resolution using a multi-echo (ME) extension of the second gradient-echo image of the MP2RAGE sequence (MP2RAGEME) sequence, resulting in complete anatomical alignment of quantitative, R1-maps, R2*-maps, T1-maps, T1-weighted images, T2*-maps, and quantitative susceptibility mapping (QSM). Quantitative MRI maps, and derived probability maps of basal ganglia structures are freely available for further analyses.

Keywords: Basal ganglia; Probabilistic maps; Subcortex; Ultra-high field 7 Tesla structural MRI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Atlases as Topic
  • Databases, Factual
  • Female
  • Globus Pallidus / anatomy & histology*
  • Globus Pallidus / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neuroimaging*
  • Red Nucleus / anatomy & histology*
  • Red Nucleus / diagnostic imaging
  • Substantia Nigra / anatomy & histology*
  • Substantia Nigra / diagnostic imaging
  • Subthalamic Nucleus / anatomy & histology*
  • Subthalamic Nucleus / diagnostic imaging
  • Young Adult