Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

Nutrients. 2020 Jul 30;12(8):2283. doi: 10.3390/nu12082283.


Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D. A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44-76 years of age were included. Two randomized groups-placebo and magnesium (500 mg/day)-were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography-tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects. The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.

Keywords: liquid chromatography—tandem mass spectrometry; magnesium; post-menopause; vitamin D.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Diet Surveys
  • Dietary Supplements*
  • Female
  • Humans
  • Magnesium / administration & dosage*
  • Middle Aged
  • Nutritional Status / drug effects*
  • Postmenopause*
  • Spain
  • Vitamin D / blood*


  • Vitamin D
  • Magnesium