The immunomodulatory role of Regnase family RNA-binding proteins

RNA Biol. 2020 Dec;17(12):1721-1726. doi: 10.1080/15476286.2020.1795584. Epub 2020 Aug 5.

Abstract

RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.

Keywords: RNA-binding protein; Regnase; immune cells; immune homoeostasis; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Disease Susceptibility
  • Homeostasis / immunology
  • Humans
  • Immunity, Innate
  • Immunomodulation*
  • Inflammation / etiology
  • Inflammation / metabolism
  • Multigene Family
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Ribonucleases / genetics
  • Ribonucleases / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • RNA-Binding Proteins
  • Transcription Factors
  • Ribonucleases

Grants and funding

This work was supported by the Clinician Scientist PRogram In Vascular MEdicine (PRIME) funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - project number MA 2186/14-1, the Friedrich-Baur-Stiftung (LMU Munich), DZHK Shared Expertise (project number 81 × 2600256) and by the DZHK Standortprojekt of Prof. C. Schulz (project number 81Z0600204).;