Abstract
Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Apoproteins / pharmacology
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Chelating Agents / pharmacology
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects*
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Humans
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Iron / metabolism
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Lactoferrin / pharmacology*
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Lactoglobulins / pharmacology*
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Species Specificity
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Streptococcus / drug effects*
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Streptococcus mutans / drug effects*
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Vibrio cholerae / drug effects*
Substances
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Apoproteins
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Chelating Agents
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Lactoglobulins
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Iron
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Lactoferrin