Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Hasna Hamdaoui; Abdelhafid Natiq; Oumaima Benlarroubia; Thomas Liehr; Hind Dehbi; Latifa Loukhmas; Fatima Chegdani

doi:10.1016/j.lrr.2020.100217

Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Leuk Res Rep. 2020 Jul 22:14:100217. doi: 10.1016/j.lrr.2020.100217. eCollection 2020.

Authors

Hasna Hamdaoui^{1

2}, Abdelhafid Natiq³, Oumaima Benlarroubia¹, Thomas Liehr⁴, Hind Dehbi⁵, Latifa Loukhmas⁶, Fatima Chegdani²

Affiliations

¹ National Reference Laboratory, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
² University Hassan II Casablanca, Faculty of sciences Ain Chock Casablanca, Morocco.
³ Département de génétique médicale, Institut national d'hygiène, Rabat, Morocco.
⁴ Department of Medical Genetics, University of Jena, Institute for Humangenetics, D-07740 Jena, Germany.
⁵ Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, Casablanca, Morocco.
⁶ Cheikh Khalifa International Hospital, Casablanca, Morocco.

Abstract

Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10-15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma. This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.

Keywords: AL amyloidosis; FISH; IGH/FGFR3; Multiple myeloma; cytogenetic analysis; del 17p.

Publication types

Case Reports