Eosinophilic esophagitis: updates on key unanswered questions

Ann N Y Acad Sci. 2020 Dec;1481(1):30-42. doi: 10.1111/nyas.14421. Epub 2020 Aug 6.


Eosinophilic esophagitis (EoE) is a clinicopathologic disease characterized by symptoms of esophageal dysfunction and esophageal eosinophilia. In the last decade, there has been a dramatic increase in its prevalence for reasons that are not completely understood. The underlying pathophysiology involves an antigen-mediated TH 2 immune response that draws eosinophils to the esophagus, causing mucosal inflammation, esophageal remodeling, and fibrosis. This ultimately leads to esophageal dysfunction that most commonly manifests as dysphagia. In this review, we will discuss updates on key questions regarding the diagnosis and treatment of EoE.

Keywords: EoE histologic scoring system; elimination diets; eosinophilic esophagitis; proton pump inhibitors; swallowed topical steroids.

Publication types

  • Review

MeSH terms

  • Deglutition Disorders* / diagnosis
  • Deglutition Disorders* / etiology
  • Deglutition Disorders* / immunology
  • Deglutition Disorders* / therapy
  • Eosinophilic Esophagitis* / complications
  • Eosinophilic Esophagitis* / diagnosis
  • Eosinophilic Esophagitis* / immunology
  • Eosinophilic Esophagitis* / therapy
  • Eosinophils / immunology*
  • Esophagus / immunology*
  • Humans
  • Inflammation / diagnosis
  • Inflammation / immunology
  • Inflammation / therapy
  • Th2 Cells / immunology*